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Sabtu, 16 Oktober 2010
Kamis, 14 Oktober 2010
Love can ease pain, say brain researchers
Love hurts, at least according to many a romantic songwriter, but it may also help ease pain, US scientists suggest.
Brain scans suggest many of the areas normally involved in pain response are also activated by amorous thoughts.
Stanford University researchers gave 15 students mild doses of pain, while checking if they were distracted by gazing at photos of their beloved.
The study focused on people early in a romance, journal PLoS One reported, so the "drug of love" may wear off.
The scientists who carried out the experiment used "functional magnetic resonance imaging" (fMRI) to measure activity in real-time in different parts of the brain.
It has been known for some time that strong feelings of love are linked to intense activity in several different brain regions.
These include areas linked to the brain chemical dopamine, which produces the brain's feel-good state following certain stimulants - from eating sweets to taking cocaine.
"Light up"
The Stanford University researchers had noticed that when we feel pain, some of the same areas "light up" on the scans - and wondered whether one might affect the other.
They recruited a dozen students who were all in the first nine months of a relationship, defined as "the first phase of intense love".
Each was asked to bring in a picture of the object of their affection and photos of what they deemed an equally attractive acquaintance.
While their brains were scanned, they were shown these pictures, while a computer controlled heat pad placed in the palm of their hand was set up to cause them mild pain.
They found that viewing the picture of their beloved reduced perceptions of pain much more than looking at the image of the acquaintance.
Dr Jarred Younger, one of the researchers involved, said that the "love-induced analgesia" appeared to involve more primitive functions of the brain, working in a similar way to opioid painkillers.
"One of the key sites is the nucleus accumbens, a key reward addiction centre for opioids, cocaine and other drugs of abuse.
"The region tells the brain that you really need to keep doing this."
Professor Paul Gilbert, a neuropsychologist from the University of Derby, said that the relationship between emotional states and the perception of pain was clear.
He said: "One example is a footballer who has suffered quite a painful injury, but who is able to continue playing because of his emotionally charged state."
He added that while the effect noticed by the Stanford researchers might only be short-lived in the early stages of a love affair, it may well be replaced by something similar later in a relationship, with a sense of comfort and wellbeing generating the release of endorphins.
"It's important to recognise that people who feel alone and depressed may have very low pain thresholds, whereas the reverse can be true for people who feel secure and cared for.
"This may well be an issue for the health service, as patients are sometimes rushed through the system, and perhaps there isn't this focus on caring that might have existed once."
Selasa, 12 Oktober 2010
Senin, 11 Oktober 2010
First human trial of embryonic stem cells
US doctors have begun the first official trial of using human embryonic stem cells in patients after getting the green light from regulators.
The Food and Drug Administration has given a license to Geron to use the controversial cells to treat people with spinal injuries.
The cells have the potential to become many of the different cell types found in the body, including nerve cells.
The trials at a hospital in Atlanta will check if the treatment is safe.Pivotal research
Geron, a biotech company based in "silicon valley" south of San Francisco, has spent $170m on developing a stem cell treatment for spinal cord injury.
The research will use cells coaxed to become nerve cells which are injected into the spinal cord.
In animal trials of the treatment, paralysed rats regained some movement.
But it is not yet known if it will offer any benefit to people with spinal cord injuries.
Every year around 12,000 people in the US sustain spinal cord injuries. The most common causes are automobile accidents, falls, gunshot wounds and sports injuries.
In the trial, patients who have sustained such an injury within the last 14 days will be given the experimental stem cell treatment.
Geron president Dr Thomas Okarma said: "When we started working with human embryonic stem cells in 1999, many predicted that it would be a number of decades before a cell therapy would be approved for human clinical trials.
"This accomplishment results from extensive research and development and a succession of inventive steps."
But it will take some time to get the results.
And there are many years of rigorous testing ahead before it can be known if the therapy is safe and effective.
Professor Sir Ian Wilmut, director of the Medical Research Council Centre for Regenerative Medicine at the University of Edinburgh, said: "This is very exciting news, however, it is very important to appreciate that the objective of trials at this stage is to confirm first of all that no harm is done to patients, rather than to look for benefits.
"Once that has been confirmed then the focus moves on to development and assessment of the new treatment."
Ben Sykes, executive director of the UK National Stem Cell Network, said: "This is indeed a significant milestone in our journey towards the promise of stem cell-based medicines.
"The global stem cell and regenerative medicine community will be awaiting the results of this safety trial with much anticipation."
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